*See Section 2, Dosage and Administration, in the Prescribing Information.

Patients were on Low Dose SPINRAZA when photographed. Patients are paid spokespersons of Biogen.
Individual results may vary based on several factors, including severity of disease, initiation of treatment, and duration of therapy.

People across a wide range of ages have been prescribed SPINRAZA

Based on patients who have been prescribed Low Dose SPINRAZA.

Over a decade

The safety and efficacy of
SPINRAZA was evaluated in the
longest clinical
trial program in
SMA to date.

3x/year after initial loading doses

SPINRAZA is delivered directly to the cerebrospinal fluid (CSF), the area surrounding the spinal cord, allowing it to be distributed to the target tissues.

Extensive real-world experience with the Low Dose Regimen of SPINRAZA across a broad range of ages

have been treated with
SPINRAZA worldwide

a broad age range of
patients has taken
SPINRAZA

have been treated with
SPINRAZA

§Based on commercial patients and early access patients receiving SPINRAZA worldwide as of April 2026.

||Based on patients receiving treatment with SPINRAZA in the US as of April 2026.

SPINRAZA clinical studies did not include sufficient numbers of subjects aged 65 and older to determine whether they respond differently from younger patients. Pivotal studies did not include adult patients.

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